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The "Garbage Collector" spikes caused by using Unity's native GUI system causes (often massive) performance losses. There are numerous threads in the forums that document this:

http://forum.unity3d.com/threads/60217
http://forum.unity3d.com/threads/76937
http://forum.unity3d.com/threads/66689
http://forum.unity3d.com/threads/39868

Please fix or replace this!